Recent Project-related Publications

2021.

  • Pereira MP, Wiegmann H, Agelopoulos K, Ständer S. Neuropathic Itch: Routes to Clinical Diagnosis. Front Med (Lausanne) 2021; 8: 641746.
  • Ruppenstein A, Limberg MM, Loser K, Kremer AE, Homey B, Raap U. Involvement of Neuro-Immune Interactions in Pruritus With Special Focus on Receptor Expressions. Front Med (Lausanne) 2021; 8: 627985
  • Solinski HJ, Rukwied R. Electrically Evoked Itch in Human Subjects. Front Med (Lausanne) 2021; 7: 627617.
  • Wolf K, Kühn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, Ständer S, Ectors P, Zahn D, Riedel YK, Thimm D, Müller CE, Kretschmann S, Kremer AN, Chien D, Limjunyawong N, Peng Q, Dong X, Kolkhir P, Scheffel J, Søgaard ML, Weigmann B, Neurath MF, Hawro T, Metz M, Fischer MJM, Kremer AE. A Group of Cationic Amphiphilic Drugs Activates MRGPRX2 and Induces Scratching Behavior in Mice. Journal of Allergy and Clinical Immunology 2021; S0091-6749(21)00229-3. Epub ahead of print.
  • Kühn H, Kolkhir P, Babina M, Düll M, Frischbutter S, Fok JS, Jiao Q, Metz M, Scheffel J, Wolf K, Kremer AE, Maurer M. Mas-related G protein–coupled receptor X2 and its activators in dermatologic allergies. Journal of Allergy and Clinical Immunology 2021; 147: 456–469.

2020

  • Rukwied R, Schnakenberg M, Solinski HJ, Schmelz M, Weisshaar E. Transcutaneous slowly depolarizing currents elicit pruritus in patients with atopic dermatitis. Acta Derm Venereol 2020; 100: 1–6.
  • Mettang T, Kremer AE. Brain teasers in pruritus—when laboratory tests will guide you. Hautarzt 2020; 71: 500–505.
    Schmelz M. Pruritus—a long journey from neurophysiology to the clinic. Hautarzt 2020; 71: 487–492.
  • Rukwied R, Thomas C, Obreja O, Werland F, Kleggetveit IP, Jorum E, Carr RW, Namer B, Schmelz M. Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin. Pain 2020; 161: 2119–2128.
  • Kühn H, Kappes L, Wolf K, Gebhardt L, Neurath MF, Reeh P, Fischer MJM, Kremer AE. Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling. Sci Rep 2020; 10: 2326.
  • Guseva D, Rüdrich U, Kotnik N, Gehring M, Patsinakidis N, Agelopoulos K, Ständer S, Homey B, Kapp A, Gibbs BF, Ponimaskin E, Raap U. Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy 2020; 50: 577–584.
  • Kremer AE, Mettang T, Weisshaar E. Non-dermatological challenges of chronic itch. Acta Dermato-Venereologica 2020; 100: 22–27.
  • Pereira MP, Derichs L, Meyer Zu Hörste G, Agelopoulos K, Ständer S. Generalized chronic itch induced by small-fibre neuropathy: clinical profile and proposed diagnostic criteria. J Eur Acad Dermatology Venereol 2020; 34: 1795–1802.
  • Pereira MP, Zeidler C, Storck M, Agelopoulos K, Philipp-Dormston WG, Zink A, Ständer S. Challenges in Clinical Research and Care in Pruritus. Acta Derm Venereol 2020; 100: adv00028.
  • Pogatzki-Zahn EM, Pereira MP, Cremer A, Zeidler C, Dreyer T, Riepe C, Wempe C, Lotts T, Segelcke D, Ringkamp M, Kremer AE, Agelopoulos K, Ständer S.. Peripheral Sensitization and Loss of Descending Inhibition Is a Hallmark of Chronic Pruritus. J Invest Dermatol 2020; 140: 203-211.e4.

2019:

  • ​Kremer AE. What are new treatment concepts in systemic itch? Experimental Dermatology 2019; 28: 1485–1492.
  • Agelopoulos K, Rülander F, Dangelmaier J, Lotts T, Osada N, Metze D, Luger TA, Loser K, Ständer S. Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced ERK1/2 activation. J Eur Acad Dermatology Venereol 2019; 33: 2371–2379.
  • Süer A, Soto Rey, I, Storck M, Pereira MP, Agelopoulos K, Ständer S, Dugas M, Bruland P. Standardbasierte vernetzte IT-Infrastruktur zur multizentrischen und multidisziplinären Verwaltung von Forschungsdaten – Integration im Rahmen der DFG-geförderten Forschergruppe „PruSearch. Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS). Dortmund, 08.-11.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. DocAbstr. 179
  • Kremer AE, Mettang T. Pruritus in systemic diseases: Common and rare etiologies. Internist 2019; 60: 814–820.
    Düll M, Kremer AE. Treatment of Pruritus Secondary to Liver Disease. Current Gastroenterology Reports 2019; 21: 48
    Schmid Y, Navarini A, Thomas ZM, Pfleiderer B, Krähenbühl S, Mueller SM. Sex differences in the pharmacology of itch therapies—a narrative review. Current Opinion in Pharmacology 2019; 46: 122–142.
  • Pereira MP, Agelopoulos K, Köllner J, Neufang G, Schmelz M, Ständer S. Selective nerve fibre activation in patients with generalized chronic pruritus: Hint for central sensitization? Acta Derm Venereol 2019; 99: 1009–1015.
  • Schmelz Martin. Itch Processing in the Skin. Front Med 2019; 6: 167
  • Gibbs BF, Patsinakidis N, Raap U. Role of the pruritic cytokine IL-31 in autoimmune skin diseases. Frontiers in Immunology 2019; 10: 1383
  • Hidding J, Agelopoulos K, Pereira MP, Conrad H, Hatt H, Lotts T, Osada N, Pogatzki-Zahn E, Schmelz M, Ständer S. Sensory qualities point to different structural and functional skin patterns in chronic pruritus patients. A translational explorative study. Acta Derm Venereol 2019; 99: 668–674.
  • Ständer Sonja. How to define chronic pruritus: Symptom or disease? Exp Dermatol 2019; 28: 1461–1465.
  • Steinhoff M, Oaklander AL, Szabó IL, Ständer S, Schmelz M. Neuropathic itch. Pain 2019; 160: S11–S16.
  • Robering JW, Gebhardt L, Wolf K, Kühn H, Kremer AE, Fischer MJM. Lysophosphatidic acid activates satellite glia cells and Schwann cells. Glia 2019; 67: 999–1012.
  • Baumann KY, Church MK, Clough GF, Quist SR, Schmelz M, Skov PS, Anderson CD, Tannert LK, Giménez-Arnau AM, Frischbutter S, Scheffel J, Maurer M. Skin microdialysis: Methods, applications and future opportunities - An EAACI position paper. Clinical and Translational Allergy 2019; 9: 24.
  • Tsianakas A, Nippe N, Hamper CM, Cordes AF, Zeidler C, Schmelz M, Ständer S. Exploratory study of intracutaneous histamine stimulation in patient populations with chronic pruritus. Acta Derm Venereol 2019; 99: 291–297.

2018:

  • Pereira MP, Mittal A, Ständer S. Current treatment strategies in refractory chronic pruritus. Current Opinion in Pharmacology 2018; 46: 1–6.
  • Steinhoff M, Schmelz M, Szabó IL, Oaklander AL. Clinical presentation, management, and pathophysiology of neuropathic itch. The Lancet Neurology 2018; 17: 709–720.
  • Meyer NH, Gibbs B, Schmelz M, Homey B, Raap U. Neurophysiologie des atopischen Pruritus. Hautarzt 2018; 69: 204–209.